alexa Abstract | Influence of s-allyl cysteine against mercuric chloride induced nephrotoxicity in albino rats

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access


Mercury (II) is a highly toxic metal which induced oxidative stress in the living organism. In the present study we examined the effect of S-Allyl cysteine (SAC) against the mercuric chloride (Hgcl2) intoxicated in albino rat model. The animals were treated with sub-leathal dose of mercuric chloride (1.23 mg/kg body wt) for 7 days. After scheduled treatetment the animals were decapitated and whole kidney tissue was used for the determination of biochemical and bioenzymological assays like lipid peroxidation (LPO) glutathione (GSH), Glutathione peroxidase (GPx), Catalase(CAT), and Superoxide dismutase (SOD) levels. During the mercuric chloride treatment the level of LPO content was significantly increased and simultaneously the level of reduced glutathione (GSH), Glutathione peroxidase (GPx), Catalase (CAT), and Superoxide dismutase (SOD) activities were decreased. The results revealed that HgCl2 induced oxidative stress and cell damage. During the recovery period, S-Allyl cysteine (5 mg/kg body wt) administrated for another 7 days on mercury intoxicated rat kidney tissue showed the decreased the level of LPO content and also restore the antioxidant level. The result suggested that HgCl2 mainly induced oxidative cell damage in kidney and administration of S-Allyl Cysteine on mercury intoxicated animal can get protection with its antioxidant effects.

To read the full article Peer-reviewed Article PDF image

Author(s): E Bharathi G Jagadeesan and T Manivasagam


Mercuric Chloride, S-Allyl Cysteine, LPO, GSH, GPx, CAT, SOD etc., mercuric chloride

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version