alexa Abstract | Influence Of Terpene Lactones Treatment On Brain Lipid Peroxidation And Antioxidant Defense Systems Of Rats After Focal Ischaemia

Indian Journal of Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Paper Open Access


The influence of terpene lactones on the lipid peroxide product, malcndialdehyde, glutathione and catalase, glutathione peroxidase, superoxide dismutase activities in rat brain as well as lactate dehydrogenase and creatine kinase activities in rat blood serum after occlusion of middle cerebral artery following reperfusion was investigated. Experimental model of the reversible middle cerebral artery occlusion without craniectomy of rat focal cerebral ischaemia-reperfusion was used. Compared to sham-operated animals, rats subjected ischaemia followed reperfusion exhibited severe neurologic deficits, ischaemia followed reperfusion increased blood serum lactate dehydrogenase and creatine kinase activities as well as brain glutathione peroxidase activity and decreased superoxide dismutase activity as well as glutathione and malondialdehyde content. Administration of terpene lactones (4,8,16 mg/kg, i.p.x2) at 15 min and 6 h after induction of just ischaemia could improve the movement function and normalize the lactate dehydrogenase and creatine kinase activities of the rat serum. Terpene lactones were also able to increase catalase and superoxide dismutase activity, ameliorate the abnormal increment of glutathione peroxidase activity but did not change glutathione content. Significant decrement of malondialdehyde content in cortex and striatum was also observed when terpene lactones were administrated. These results suggested that terpene lactones could affect the process of oxidative damage. This perhaps was related to the beneficial role in the protection against ischaemia-reperfusion injury.

To read the full article Peer-reviewed Article PDF image

Author(s): YuYang Zhang Qing Hai Yu Song You Li Sheng YiMei Wang YuLi Wan

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us