alexa Abstract | Influence on some female fertility hormonal response in wistar albino rats: Possible contraceptive role for methanol leaf extract of Ocimum gratissimum ?

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access


Ocimum gratissimum is a well-known medicinal plant. Folklore claims its use in management of headache, fever, diarrhea, pneumonia etc. Results of several research works support most of the claims. There is however scanty information on its effect on female fertility hormones production. This study was therefore designed to investigate the effect of its methanol extract on some fertility hormones in female albino rats. The animals were divided into three groups 1,2 and 3 representing those that received higher dose, lower dose of the extract and feed only which served as control. The extract was administered orally for 21 days at the end of which the animals were sacrificed and blood collected for the assay. The serum level of prolactin, progesterone, luteinizing hormone, estradiol, follicle stimulating hormone and testosterone were determined using enzyme-linked immunosorbent assay (ELISA) technique. Data from the study were analyzed using ANOVA at 95% confidence level. Results showed that administration of methanol extract of Ocimum gratissimum caused non-significant (P > 0.05) difference in estradiol concentration in group1(1.84± 0.16) and a non-significant (P > 0.05) increase in group 2 (2.06±0.24) compared to the control(1.74±0.05).The result also showed a dose dependent significant (P <0.05) decrease in serum testosterone level in the test groups (34.29±3.32) (30.46±0.50) compared to the control (35.18±2.31). Level of follicle stimulating hormone decreased non-significantly (P > 0.05) (9.25±0.93), (10.22±2.31) compared to the control(11.83±2.14). Equally a non-significant decrease was seen in the level of luteinizing hormone in both test groups (9.11± 0.94) (8.64±0.72) compared to the control group (9.68± 1.26). Non-significant increases were also observed in prolactin (7.69± 1.17), (7.42± 3.64) and progesterone (7.66± 0.96), (7.19±0.96) levels in the test groups compared to the control control group (6.64±2.33) (6.91± 0.60).The findings in this study have important implications for female contraceptive development.

To read the full article Peer-reviewed Article PDF image

Author(s): Egba Simeon I Omodamiro Olorunsola D Obike Joy C and Ali Ezinne S


Hormones, Elisa, Albino Rats, Ocimum gratissimum, albino rats,fertility hormone

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version