alexa Abstract | Inhibition of UVB induced oxidative stress in Catla catla & Glutamate pyruvate transaminase (GPT) activities by embelin using molecular docking tool

Journal of Chemical and Pharmaceutical Research
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Abstract

The present study aimed to evaluate the inhibitory effect of embelin against UVB induced oxidative stress using in vivo (Catla catla) fish model. Larve [Catla catla (1.2+0.01 mg)] were fed with three types of diets control diet (Group I & Group II with and without UVB exposure) and diet containing 0.1 & 0.5% embelin (Group III & IV) respectively. After 40 days of feeding, embelin fed fishes (Group III & IV) were exposed to UVB radiation (145 μW/cm2) for six days for 10 minutes. Survival rate of fishes after UVB exposure was recorded. Tissue samples were collected from the whole body and used for biochemical and enzyme analyses. In additional to these, we also docked embelin, 5-O-methyl embelin and vilangin with glutamate pyruvate transaminase (GPT) chain-A using Discovery Studio Version 3.1. Results revealed that statistically significant difference in the survival rate was observed between the control verses embelin fed fishes. Similarly, significant reduction in Glutamate oxaloacetate transaminase (GOT) and Glutamate pyruvate transaminase (GPT) enzymes were observed in the embelin fed fish groups. With reference to docking studies, vilangin fails to dock, whereas embelin and 5-O-methyl embelin showed interaction energy of -38.0 & -38.3 kcal/mol respectively. Thus, the present study suggested that embelin protects Catla catla (fish) against UVB induced oxidative stress, which could also substantiate our earlier in vitro study.

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Author(s): N Radhakrishnan Kamal Rullah Rina Chakrabarti and A Gnanamani

Keywords

molecular docking

 
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