alexa Abstract | Inhibition of UVB induced oxidative stress in Catla catla & Glutamate pyruvate transaminase (GPT) activities by embelin using molecular docking tool

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access

Abstract

The present study aimed to evaluate the inhibitory effect of embelin against UVB induced oxidative stress using in vivo (Catla catla) fish model. Larve [Catla catla (1.2+0.01 mg)] were fed with three types of diets control diet (Group I & Group II with and without UVB exposure) and diet containing 0.1 & 0.5% embelin (Group III & IV) respectively. After 40 days of feeding, embelin fed fishes (Group III & IV) were exposed to UVB radiation (145 μW/cm2) for six days for 10 minutes. Survival rate of fishes after UVB exposure was recorded. Tissue samples were collected from the whole body and used for biochemical and enzyme analyses. In additional to these, we also docked embelin, 5-O-methyl embelin and vilangin with glutamate pyruvate transaminase (GPT) chain-A using Discovery Studio Version 3.1. Results revealed that statistically significant difference in the survival rate was observed between the control verses embelin fed fishes. Similarly, significant reduction in Glutamate oxaloacetate transaminase (GOT) and Glutamate pyruvate transaminase (GPT) enzymes were observed in the embelin fed fish groups. With reference to docking studies, vilangin fails to dock, whereas embelin and 5-O-methyl embelin showed interaction energy of -38.0 & -38.3 kcal/mol respectively. Thus, the present study suggested that embelin protects Catla catla (fish) against UVB induced oxidative stress, which could also substantiate our earlier in vitro study.

To read the full article Peer-reviewed Article PDF image

Author(s): N Radhakrishnan Kamal Rullah Rina Chakrabarti and A Gnanamani

Keywords

molecular docking

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords