alexa Abstract | Insilico biological evaluation of newly synthesized 1'-(4-Bromophenyl)-4'- {4-[(2-oxo-1,2,3,4-tetrahydronaphthalen-2-ylidene) methyl] phenyl}-3'',4''- dihydroacenaphthylene-1-spiro-2'-pyrrolidine-3'-spiro-2''-naphthalene- 2,1''(1H,2''H)-dione against fungal target

International Journal of Drug Development and Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Abstract

Fungal infection is the commnest problem everywhere. Depending on the types of starin involves the strategy applies. Various spectral antibiotics have been incorporated as antifungals but fail to inhibit. This pilot study establishes the new synthesied compound 1'-(4-Bromophenyl)-4'-{4-[(2- oxo-1,2,3,4-tetrahydronaphthalen-2-ylidene)methyl]phenyl}-3'',4''- dihydroacenaphthylene-1-spiro-2'-pyrrolidine-3'-spiro-2''-naphthalene- 2,1''(1H,2''H)-dione tested against the fungal target. Selected target retrieved from database and selected using biosynthetic pathways by using the cellular mechanism. This can be act as a check point to interrupt the pathway. Newly introduced pyrolidine based compound were dock with the glucose 6 phosphate synthase insilico docking tools and analyzed by X ray crystallography. Docking by molegro virual docker (MVD) shows good docking score and poses. It shows -141kcal/mol in first pose which considers as a based score and structure based binding site. In conclusion, the synthesized compound can designate as drug.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Saravanan B Akhilesh Upgade Manivannan V

Keywords

Drug development, novel drug, antifungal drug

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us