alexa Abstract | Insilico predictions of inhibitors of novel statin structural analogues with HMG-CoA reductase

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access

Abstract

This paper deals to design a potent drugs for cardiovascular disorders in which HMG Co A is the main target. Objective of our study is to optimize the activity of statin group of drugs against HMG - CoA reductase. : Statin groups like Simvastatin, Lovastatin, Fluvastatin and Atorvastatin are selected for this study. Malegro Virtual Docking (MVD) was used for statin analogues have been designed on the basis of their closest interaction of the native co crystallized protein ligand. All statin analogues have been showed with commercial software Malegro Virtual Docking trial version software and then docked against the target enzyme 1HWA, 1CQP, 1HWI, 1HWKrespectively. Docking studies of designed statin analogues showed conformer generation on all molecules. Similar compounds having 4168, 4144, 158, and 5199conformers are Simvastatin, Lovastatin, Fluvastatin and Atorvastatin respectively. Statins were designed by interaction of hydrogen bond with their respective target site. A molecule showing highest hydrogen bond energy with target was considered as probable potent drug which further needs to be evaluated in laboratory.

To read the full article Peer-reviewed Article PDF image

Author(s): S Allimalarkodi T Sudha V Ida Christy and M Karpagavalli

Keywords

Cardiovascular diseases, HMG-Co A, Statins, Docking studies, Hydrogen bonding.

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords