alexa Abstract | Inter-individual variation in pharmacokinetics of proton pump inhibitors in healthy Indian males

Indian Journal of Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Paper Open Access


Proton pump inhibitors have revolutionized the management of acid-peptic disorders in recent years. They have a broadly similar mechanism of action and are extensively metabolized in the liver via cytochrome P450 2C19 and 3A4 enzymes. A wide inter-individual variability in pharmacokinetics due to polymorphism in cytochrome P450 2C19 has been demonstrated for the first-generation proton pump inhibitors. Since this report, cytochrome P450 2C19 related pharmacokinetics of proton pump inhibitors has been demonstrated in populations other than Indians. Hence, it was of interest to explore inter-individual variations in pharmacokinetics of proton pump inhibitors, i.e., pantoprazole, omeprazole, rabeprazole, and lansoprazole in healthy Asian Indian male subjects after oral administration of the respective formulations. In this report, the pharmacokinetics of four proton pump inhibitors were investigated after single oral dose administered to healthy Indian male subjects. The plasma concentration time profiles of subjects showed high inter-individual variations for all four proton pump inhibitors. Furthermore, the subjects can be classified in groups based on the various patterns of pharmacokinetic profiles. Subjects with higher concentrations of the drug can be grouped as apparent poor metabolizers of the drug and subjects with comparatively lower concentrations of the drug can be categorized as apparent extensive metabolizers of the drug. The mean pharmacokinetic parameters C max , T max , AUC 0-t , AUC 0-00 and t 1/2 for the various groups were statistically significantly different from each other. The results demonstrated that the phenotypic polymorphism and extent of variability in plasma concentration - time profiles of proton pump inhibitors in healthy Indian males were in line with the other populations. Moreover, this information will be helpful in deciding the dose regimens that take the differences in drug metabolic capacity into account as Klotz has already suggested that the lower dosage of pantoprazole should be given to patients of poor metabolizer group with severe liver impairment for the same pharmacodynamic response.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Shubha Rani Harish Padh

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us