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The elevated level of high-sensitivity C-reactive protein (HSCRP) and atherosclerosis are associated with high mortality in type 2 diabetic patients. The HSCRP correlates with atherosclerosis and insulin resistance in type 2 diabetic patients. IL-6 is a cytokine (one of a class of immune system regulators) it plays a critical role, in acute phase of inflammatory reaction to cellular injury. The aim of the study is a comparison between metabolic profiles in Iraqi type 2 diabetic patients with low HSCRP levels and those with elevated HSCRP levels; independent predictors of the HSCRP in these populations were evaluated. To estimate the pro inflammation cytokines that have been associated with insulin resistance such as IL-6 in type 2 diabetic patients. This study consisted of 50 Iraqi patients with type 2 diabetes with elevated HSCRP group (0.3–1.0 mg/dl, age: 57±5 years, mean ± S. D.) and a control group of 50 age-matched diabetic patients with low level of HSCRP (<0.3 mg/dl, 57±6 years). IL-6 was measured (by enzyme linked immunosorbant assay, ELISA) . The body mass index (BMI) values, waist circumferences and the waist-to-hip ratios were higher in the high HSCRP group than in the low HSCRP group. Fasting blood glucose (FbG; and insulin concentrations, and the homeostasis model assessment (HOMA) index, were significant higher in the elevated HSCRP group than in the low level of HSCRP group. IL-6 showed a significantly higher serum level in elevated HSCRP patients than low level of HSCRP group. These results indicate that the elevated level of HSCRP in Iraqi patients with type 2 diabetes is characterized by atherosclerosis and insulin resistance, with a highly significant increase in the levels of IL-6 is in the high HSCRP group than in the low HSCRP group.
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Author(s): Dr Mohammed Kamal Rasheed Dr Manal Kamal Rasheed Dr Halla Ghazi Mahmood
IL-6, high-sensitivity C-reactive protein in atherosclerosis, type2 diabetes.