alexa Abstract | Intrarenal angiotensin II plays an important role in renal fibrosis in primary IgA nephropathy.

Biomedical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)


Objective: To investigate the relationship of intrarenal angiotensin II (Ang II) expression with clinicpathological injury index and intrarenal expression and regulation of RAS (renin-angiotensin system) components in IgAN (immunoglobulin A nephropathy) patients.

Material and methods: The expression of intrarenal renin, angiotensinogen (AGT), Ang II, Ang IIreceptor was examined by immunohistochemistry staining (IHCS). Clinic-pathological injury index included blood pressure, estimated glomerular filtration rate (eGFR), proteinuria and Katafuchi score.

Results: Positive IHCS area of intrarenal Ang II was 32.73 ± 14.74%. There was a negative correlation between intrarenal Ang II and eGFR (r=-0.61, P<0.01), index of glomerular hypercellularity (ρ=-0.35, P<0.05).Intrarenal Ang II correlated positively with pathological chronicity index (ρ=0.39, P<0.05), index of interstitial cell infiltration (ρ=0.52, P<0.01), index of tubular atrophy (ρ=0.51, P<0.01), index of vessel wall thickening (ρ=0.36, P<0.05) and index of arteriolar hyalinosis (ρ=0.36, P<0.05). Intrarenal Ang II positively correlated with intrarenal renin and AGT (r=0.43, P<0.01 and r=0.3, P<0.05, respectively). No other correlation was evidenced between intrarenal expression of explored RAS components.

Conclusions: Intrarenal Ang II plays an important role in renal fibrosis in IgAN, particularly at the tubulointerstitial level. Moreover, there is a tight regulation of the intrarenal RAS components in IgAN.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Han Wenlun Zhu Yunyun Zhong Yu Ding Huideng


IgA nephropathy, Renin-angiotensin system, Estimated glomerular filtration rate, Katafuchi score, Chronicity, #

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version