alexa Abstract | Investigating multidrug efflux pumps in relation to the antibiotic resistance pattern in Escherichia coli strains from patients in Iran

Biomedical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access


Objective: To investigate antibiotic resistance pattern of Escherichia coli strains isolated from patients admitted to the Shahid Mostafa Khomeini hospital in Behbahan city and survey its relationship with the presence of efflux pumps.

Methods: In this study, 180 isolates of E. coli were collected from Shahid Mostafa Khomeini hospital. After confirmation of strains by standard culturing methods and biochemical tests, their antibiotic resistance was evaluated with agar diffusion test and CLSI standards guidelines. The genes encoding the AcrA-AcrB-TolC efflux pump were identified with PCR.

Results: The percentages of resistance of the E. coli isolates to some antibiotics were as follow: novobiocin and rifampin, 68.9%; erythromycin, 52.8%; tetracycline, 52.2% and nalidixic acid, 51.7%. Isolates were sensitive to amikacin, 89.4%; tobramycin, 85.6%; meropenem, 81.7%; chloramphenicol, 77.8% and piperacillin, 65.6%, respectively. 110 (61.1%) strains from 180 taken isolates were found with multidrug- resistance (MDR) but no pandrug-resistance (PDR) was observed. 51.1%, 75.0% and 69.4% of isolates had genes acrA, acrB and tolC, respectively. Comparison of the results of antibiogram obtained from PCR with the two-way correlation test showed that there is a significant positive correlation between the presence of efflux pumps and resistance to antibiotics (excluding carbenicillin, meropenem, chloramphenicol, cefotaxime, rifampin and novobiocin).

Conclusion: Due to differences in antibiotic resistance in different strains is required using antibiotic resistance pattern for experimental and specific treatment of patients.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Farshid Kafilzadeh Farnoosh Farsimadan


Multi-drug resistance, E. coli, Antibiotic resistance, Efflux pumps, Behbahan, #

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

neuro[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version