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Two doses (100 mg/kg and 200 mg/kg p.o) of the Albizia julibrissin essential oil (AJEO) were subjected for the evaluation of learning and memory enhancing activity against amnesia induced by scopolamine (0.4mg/kg, i.p) in young mice. Piracetam (400 mg/kg i.p) was served as standard in both the models. Biochemical parameter like Anticholinesterase activity was evaluated. Both the lower (100mg/kg) and higher dose (200mg/kg) of AJEO has shown dose dependent significant decrease in Transfer latency (TL) by EPM and decrease in AChE activity in brain estimation which in terms indicate improved learning and memory when compared with scopolamine group. Sub-acute treatment (long term) was more significant than acute treatment (short term) on learning and memory enhancing activity.
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Author(s): Dhanya K Satish S Hegde K Shabaraya AR
Cognition, Dementia, Learning and memory, AChE activity