alexa Abstract | Invitro comparison of dissolution profiles and antimicrobial activity of three brands of amoxicillin from Mangalore

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access


To know whether the generic formulations of Amoxici llin Trihydrate is as effective as branded formulat ion. A branded, generic branded and generic version of Amo xicillin trihydrate dispersible tablets were procur ed and coded as A, B and C. They were compared for the disintegr ation time, dissolution time and in-vitro antimicro bial activity. The disintegration time was measured using the disi ntegration apparatus. The dissolution rate (0.1 N H Cl at 37 0 C) was measured using USP2 paddle apparatus. The antim icrobial activity was assessed on E.coli grown on M ueller Hinton agar. The disintegration times were (A) 21 s econds, (B) 51 seconds and (C) 80 seconds. The diss olution rates at 15 minutes were 98.1%, 95.7% and 83.9%. Th e zone of inhibition was found to be (A) 2.9 cms, ( B) 2.6 cms and (C) 2.2 cms. The results show that the 3 produc ts are similar and interchangeable.

To read the full article Peer-reviewed Article PDF image

Author(s): Vikram Rao J Nagendra Nayak I M J Vikshitha R


Invitro, dissolution, antimicrobial activity, amoxicillin, Invitro, dissolution, antimicrobial activity, amoxicillin

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us