alexa Abstract | In-Vivo Genotoxicity and Cytotoxicity Study of Prazosin HCl

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access


The aim of performing this work is to study and evaluate Genotoxicity and Cytotoxicity of Prazosin HCL in mice. The animals were treated with Prazosin (PZ) at the doses of 5, 15, 25 mg/kg/body weight intraperitoneal (IP) for single dose (14 days) toxicity studies. Different methods were used to perform the study like Measurement of body weight, organ weight and food intake, Estimation of Malondialdehyde (MDA) level, Estimation of Reduced Glutathione (GSH) level, For evaluation of Genotoxicity following parameters has been evaluated: Micronucleus assay in bone marrow, Micronucleus assay in peripheral blood, Determination of DNA damage: Metaphase chromosome analysis, Determination of DNA damage: DNA fragmentation assay, Determination of Cytotoxicity: Histological examination.The results obtained clearly demonstrate that PZ produced toxic responses at the higher dose in the hepatocytes as evident from increased MDA level, decreased GSH level, DNA damage, increased DNA fragmentation in mice. Also, it is interesting that in bone marrow cells, PZ induced structural chromosomal aberrations, and significantly DNA strand breakage observed. So it is considered as Genotoxicity toward the bone marrow cells and to the hepatocytes of mice. The present study provided evidence that Prazosin induced significant genotoxic effects in mice at its equivalent hepatotoxic dose level.

To read the full article Peer-reviewed Article PDF image

Author(s): Deepika Devnani Lubhan Singh Pushpendra Kumar Jain and Amit Kr Lala


Bone marrow, Cytotoxicity, Prazosin, Genotoxicity, Liver, Mice, Oxidative stress, Cytotoxicity

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us