alexa Abstract | Isolation and evaluation of fenugreek seed husk as a granulating agent

Indian Journal of Pharmaceutical Sciences
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Abstract

In the present study a relatively simple method for the separation of husk from the seeds of Trigonella-foenum graecum (fenugreek) was developed. The entire seeds were subjected to size reduction followed by successive extractions with chlorinated hydrocarbons to separate the husk from the 'core and oily portion' to yield about 40%w/w of the husk. The dried husk was further powdered to 180 - 250 µ. It was characterized for various physicochemical parameters including swelling index, particle size distribution and flow properties. Use of fenugreek husk as a binding/granulating agent in solid dosage forms was also investigated. Diclofenac sodium and paracetamol were the model drugs of choice for optimizing the binding properties of husk in tablets using fenugreek husk dispersion, comparing the results against starch paste. Friability, hardness, disintegration, weight variation and dissolution were the parameters of comparative studies. Fenugreek husk dispersion was found to be superior over starch paste, on the basis of the selected parameters. The maximum concentration required of the husk as a binding agent was 4 -5% of the dosage form, which is relatively low as compared to starch.

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Author(s): Amelia Avachat KN Gujar VB Kotwal Sonali Patil

 
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