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The main objective of this experiment was to investigate the antiinflammatory activity of Citrullus lanatus methanol extract (ME) and its fractions in adult male albino rats. Citrullus lanatus has been traditionally used for various disease and disorders. The phytochemical evaluation of methanolic seeds extract showed the presence of carbohydrate, alkaloids, steroids, saponins, flavonoids, tannins and phenolic compounds. The present work revealed that the inflammatory tissue damage was due to liberation of ROS from phagocytes invading inflammation sites. By this it proved that, oral methanolic extract of Citrullus lanatus was found to have anti-inflammatory activity & it may be due to its free radical scavenging activity. 200 mg/kg of methanolic extract of Citrullus lanatus had shown significant (p<0.05) antiinflammatory activity during 30min, 1 hr & 3 h. On the basis of the results obtained in present investigation after fractionation, it is possible to conclude that amongst all the fractions non-aqueous fraction (200 mg/kg) of methanolic seeds extract of Citrullus lanatus has most significant (p<0.01, p<0.001) anti-inflammatory activity after 30 mins,1h, 2h, 3h and 5h.
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Author(s): Sarika Jain E Edwin Jarald Sheeja Edwin Jyotiranjan Roul
Citrullus lanatus, isolation, fractionation, anti-inflammatory activity.