alexa Abstract | Jak2 Inhibitors are the solution for Myelo Proliferative Disorders

International Journal of Drug Development and Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Abstract

The recent discovery of JAK2 –activating mutations as a casual event in the majority of patients with Philadelphia chromosome negative (ph-)myeloproliferative disorders (MPDs) prompted many pharmaceutical companies to develop JAK2- selective inhibitors for the treatment of MPD’S . JAK2 inhibitors effectively reduce JAK2 driver phosphorylation of signal-transducer and activator of transcription 5,and cell proliferation and cell survival in JAK 2 activated cells in vitro and invivo. The results of ongoing clinical trials will allow further evaluation of clinical benefits and safety of these compounds. In this review the authors summarize the status of JAK2 inhibitors in development and discuss their benefits and challenges.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Siva jyothi Buggana Swetha PadigelaSafuara Ayesha mujeebPriyanka kuthadi

Keywords

Essential thrombocythemia (ET), JAK2V617F, Myeloproliferativeneoplasms (MPN), Polycythemiavera (PV), Thrombopoietin receptor(TPO).

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords