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Research Paper Open Access
Microbial kinetics have been employed to study the mechanism of antibacterial activity of chloroquine on S. aureus. Cultures treated with the drug in growth medium showed biphasic steady-state generation curves, the apparent rate constant for the phase I was smaller than for phase II. The bacteriostatic activity of the drug was associated with the first phase of drug-bacteria reaction, which was also affected by changes in pH of the growth medium.