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Context Acute pancreatitis is often caused by acute alcoholic intoxication or biliary stone migration. Other etiologies are lessfrequent. Case report We report an exceptional case of kissing ulcer as the cause of an acute pancreatitis due to theperforation of the posterior ulcus into the pancreas. More remarkable is the association of a left portal branch thrombosisand a portal biliopathy. Conclusion We describe a case of acute pancreatitis of unusual origin, associated with an equallyuncommon pathology which is portal cavernoma. A literature review is then exposed to try to ascertain if there is aconnection between these two entities.