alexa Abstract | Levofloxacin as potent chiral selector for enantioseparation of DL-amino acids using ligand exchange chromatographic approach on TLC

Journal of Chemical and Pharmaceutical Research
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Original Articles Open Access

Abstract

A simple, efficient, cost-effective and less time consuming analytical method was developed to separate the enantiomers of certain DL-amino acids using Levofloxacin as chiral selector. Levofloxacin was used as chiral ligand exchange reagent on TLC plates. Chiral separation was achieved under different conditions like pH of reaction mixture, mobile phase, polarities of solution or reaction mixture and temperature. Separation mechanism of the enantioseparation was also discussed.

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Author(s): Manohar Lal Jaspreet Kaur Yogesh Kumari and Radha Raman Maurya

Keywords

Levofloxacin, DL-Amino acids, Enantioseparation and Ligand exchange chromatography, enantioseparation

 
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