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In the literature, there is a growing search for new inhibitors of acetylcholinesterase (AChE) enzyme in extracts and essential oils of plants. Inhibition of AChE increases the acetylcholine concentration in the synapse, region of communication between neurons in the brain, which would decrease and retard the progression of symptoms in the treatment of Alzheimer’s disease (AD). This article brings several screenings with extract and constituents isolated of Brazilian plants, as well as essential oils and their constituents as acetylcholinesterase inhibitors (AChEI), being suggested as promising for elaboration of new herbal medicines. Promising pre-clinical studies were conducted with compounds isolated from some of these Brazilian species namely Platonia insignis (bacurizeiro), Citrus limon (lemon), Citrus sinensis (orange), Mangifera indica (mango) and Kalanchoe brasiliensis (courama branca), for the prevention or progression of AD.
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Author(s): Feitosaa CM Cavalcante AN Morais Chaves SK Arajoa LS
Medicinal plants, Alzheimerâ€™s disease, Acetylcholinesterase inhibitors, preclinical studies