alexa Abstract | Methyl-5 (6) piperidinocarbonyl benzimidazole-2-carbamate : an antifilarial agent.

Indian Journal of Pharmaceutical Sciences
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Research Paper Open Access

Abstract

The antifilarial activity of a synthetic agent, methyl-5 (6) piperidino-carbonyl benzimidazole-2-carbonate (C.D.R.I. Comp. No. 81/504) was evaluated against three different filarial species in rodents at various dose levels. It exerted 100 percent microfilaricidal action against Litomosoides carinii at 3 mg/kg, i.p. x 5 days in cotton rats and at 50 mg/kg i.p. x 5 days against Dipetalonema viteae and Brugia malayi in mastomys, on day 35,42 and 56 respectively. All the adults of L. carinii died at 10 mg/kg while worms of other two species, D. viteae and B. malayi were killed respectively at 12.5 and 50 mg/kg x 5 days. At 3000 mg/kg by oral route and at 300 mg/kg by i.p. route, the agent did not produce any untoward reactions in mice. The compound thus deserves further investigations.



Author(s): N Fatma PK Murthy S Kumar RK Chatterjee K umar Shiv

 
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