alexa Abstract | Methyl-5 (6) piperidinocarbonyl benzimidazole-2-carbamate : an antifilarial agent.

Indian Journal of Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Paper Open Access


The antifilarial activity of a synthetic agent, methyl-5 (6) piperidino-carbonyl benzimidazole-2-carbonate (C.D.R.I. Comp. No. 81/504) was evaluated against three different filarial species in rodents at various dose levels. It exerted 100 percent microfilaricidal action against Litomosoides carinii at 3 mg/kg, i.p. x 5 days in cotton rats and at 50 mg/kg i.p. x 5 days against Dipetalonema viteae and Brugia malayi in mastomys, on day 35,42 and 56 respectively. All the adults of L. carinii died at 10 mg/kg while worms of other two species, D. viteae and B. malayi were killed respectively at 12.5 and 50 mg/kg x 5 days. At 3000 mg/kg by oral route and at 300 mg/kg by i.p. route, the agent did not produce any untoward reactions in mice. The compound thus deserves further investigations.

Author(s): N Fatma PK Murthy S Kumar RK Chatterjee K umar Shiv

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us