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Review Article Open Access
The SEPT9 gene methylation assay has been proved to be a reliable assay for CRC detection by many studies. Due to the highly sensitive properties of the assay, analysis of quantitative data is crucial for qualitative interpretation of the test results. However, different analysis methods used currently in data interpretation led to variation in test sensitivity and may affect the test effectiveness in CRC detection. Here we review the methods used in data interpretation in major clinical trials performed so far, and provide our recommendations for data interpretation in future practice.
Septin 9, SEPT9, Septin, Methylation, Colorectal cancer, Adenoma, FOBT, FIT, Colorectal Surgery, Benign Colorectal Disease, Crohns Disease