alexa Abstract | MicroRNAs as Indicators and Predictors of Pancreatic Adenocarcinom

JOP. Journal of the Pancreas
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Review Article Open Access

Abstract

Chronic pancreatitis is a chronic inflammatory disorder, triggered by various factors. Several factors increase the risk of the development of pancreatic adenocarcinoma, including age, smoking, and chronic alcohol consumption. Predictors for cancer development are currently not available in the stage of chronic pancreatitis; and technical procedures such as endoscopic ultrasound or MRI scanning techniques are often hampered by a low specificity of cancer prediction. Thus, pancreatic cancer is often diagnosed at advanced stages, and chemotherapy does not improve the outcome dramatically. A reliable test in blood, tumor or bile would help to detect the tumors at earlier stage. Most interestingly, a new predictive parameter has recently evolved since MicroRNAs have been associated with cancer development and progression, and recent scientific evidence suggests that MicroRNAs can be regarded as “tumor markers” since several molecules are expressed at high levels in the tumors themselves throughout different patient groups. MicroRNAs expression profiles even seems to classify human gastrointestinal cancer better that MicroRNAs –protein expression profiles. Among the various molecules, miR- 21, miR-34a, miR-198, mir-155 and miR-217 have been shown to be highly specific as biomarkers differentiating between chronic pancreatitis and pancreatic ductal adenocarcinoma. Also, MicroRNAs-196a and -196b have been described as potential biomarkers for the early detection of familial pancreatic cancer. Pilot studies now aim to develop a diagnostic test for pancreatic ductal adenocarcinoma based on differential expression of select MicroRNAs in plasma and bile, not only to predict cancer development but also to understand molecular basis of cancer pr ogression.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Christian Prinz and David Weber

Keywords

MicroRNAs, Pancreatic Neoplasms, Pancreatic Adenocarcinoma

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords