alexa Abstract | Microwave assisted novel synthesis and antibacterial evaluation of 1-(2-methyl-2,5-substituted diphenyl-1,3,4-oxadiazol-3(2H)-yl)ethanone derivatives

Journal of Chemical and Pharmaceutical Research
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In continuation of our interest regarding microwave assisted synthesis, we have carried out Novel synthesis of 1-(2- methyl-2, 5 substituted diphenyl-1, 3, 4-oxadiazol-3(2H)-yl) ethanone derivatives (4a–4i) by cyclisation of N'-[(1Z)- 1-(substituted phenyl) ethylidene] benzohydrazide derivatives (3a-3i) in presence of acetic anhydride on solid support silica gel under the microwave radiation. All the synthesized compounds were characterised on the basis IR, 1H NMR, 13C NMR and Mass spectral analysis also synthesized compounds were screened for their antibacterial activity against Gram positive and Gram negative bacteria.

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Author(s): Pravina B Piste Shubhangi P Waghamale and Bhagyashree A Lole


Oxadiazole, solid support silica, Microwave, Antibacterial activity, Microwave assisted

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