alexa Abstract | Microwave Assisted one Pot Synthesis of Pharmaceutical Pyrazole Derivatives

Asian Journal of Biomedical and Pharmaceutical Sciences
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A simple, efficient and one pot microwave assisted synthesis of (5-amino-3-aryl-1H-pyrazol-1-yl) (6-chloropyrazin-2-yl) methanones is described. The molecules were synthesized by the cyclocondensation reaction of 6-chloropyrazine-2-carboxylic acid hydrazide and substituted benzoylacetonitriles by irradiation under microwave energy, to provide in high yields with clean and scalable reactions. The synthesized compounds were characterized by IR, 1H-NMR and mass spectral data. The plausible mechanism of the reaction is proposed.

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Author(s): Harendra K Sharma Manoj Sharma


Microwave, Pyrazole, Cyclocondensation, Characterization

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