alexa Abstract | Microwave assisted synthesis of 6-methyl-1,2,3,4-tetrahydro-N-aryl- 2-oxo-4-arylpyrimidine-5-carboxamide and 3, 4-dihydropyrimidin- 2(1H)-ones under solvent free conditions

Journal of Chemical and Pharmaceutical Research
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Original Articles Open Access


6-Methyl-1,2,3,4-tetrahydro-N-aryl-2-oxo-4-arylpyrimidine-5-carboxamide and 5-unsubstituted 3, 4-dihydropyrimidin-2(1H)-ones have been synthesised from three component cyclocondensation of N-aryl-3-oxobutanamide/acetophenone, aldehyde and urea /thiourea in presence of PTSA under solvent free microwave irradiation.

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Author(s): I T Phucho S Tumtin A Nongpiur R Nongrum and R L Nongkhlaw


Pyrimidine-5-carboxamide, dihydropyrimidin-2(1H)-ones, N-phenyl-3- boxobutanamide, solvent free , PTSA

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