alexa Abstract | Microwave assisted synthesis of Isoflavones

Journal of Chemical and Pharmaceutical Research
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Original Articles Open Access

Abstract

Isoflavones are phenolic natural products occur in nature in plants, they are secondary metabolites. They are molecules of flavonoid family. Isoflavones are derived from 3-phenylchromen-4-one. They possess diversified biological activities. Therefore, various organic/medicinal chemists around the world have developed various synthetic routes methodologies to achieve the target molecules. We wish to report here with a green approach. In our methodology Deoxy benzoin was obtained by treating a substituted phenol with phenyl acetic acid in presence of BF3etherate as a Lewis acid. This intermediate in presence of Vilsmeir reagent and DMF was cyclized under microwave to furnish the product in good yield.

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Author(s): R B Kshatriya Y I Shaikh and G M Nazeruddin

Keywords

Flavonoids, Isoflavones, Biologically Active, Green Chemistry, Microwave, Isoflavones

 
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