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Several 1,3-thaizolidin-4-ones bearing variously substituted diaryl ring at C-2 and N-3 positions have been synthesized utilizing microwave irradiation and evaluated for their antiHlV and antiYFV activities. The results of the in vitro antiHlV evaluation showed that compound DS13 proved to be an effective inhibitor of HIV-1 replication with EC50 of 10 Î¼M, CC50 of 120 Î¼M and percentage protection of 104%.
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Author(s): D Sriram P Yogeeswari T G Ashok Kumar