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The most challenging goal in the management of diabetic patient is to achieve normal blood glucose levels caused by post-prandial hyperglycemia (PPHG) or hyperinsulinemia, the individual risk factor contributes to the development of macrovascular complications. Synthetic hypoglycemic agents are available which has its own limitations and serious side-effects. The present study deals about the development of a common small molecular structure by enhancing the molecular descriptors required for binding with α-glucosidase and α-amylase enzymes, the two major targets of PPHG and to develop a monosaccharide-type inhibitor with many insights derived from pharmacophore studies, molecular alignment and molecular docking studies of known inhibitors. A hypothesis was designed which suggest the essential and/or minimal requirement of molecular descriptors to be an efficient binder of these two hydrolytic enzymes and subsequently, molecules with naturally occurring flavonoid structural architecture obeying the hypothesis was developed and evaluated in silico.
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Author(s): Kumar SP Kapopara RG Patel SK Patni MI JasraiYT Pandya HA RawalRM
Post-prandial hyperglycemia, Molecular descriptors, α-glucosidase, α-amylase, Pharmacophore features, Molecular docking, Hypothesis design