alexa Abstract | Molecular docking of HBXIP with Chemical Analogues in comparison with Epicatechin

International Journal of Drug Development and Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)


Background: HBXIP is an oncogenic viral protein binds to HBx leading to Hepatocellular carcinoma. The main aim of the present study is to target the HBXIP with commercial available antiviral and anticancer drugs comparing it with Epicatechin phytochemical. Methodology: HBXIP structure was retrieved from Protein Databank named 3MSH. The molecules were retrieved from ChemSpider, and generated using ISIS Draw. ADME and Toxicity of the chemical compounds were studied using Accelerys TopKat. Then the interaction of the compounds targeted to HBXIP was studied using Docking using Accelerys Discovery Studio. Conclusion: Final results were compared to the phytochemical Epicatechin interactions. This study is useful for development of Prodrug against HBXIP to inhibit the binding of HBXIP to HBx.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): V Sathya N Soumya V K Gopalakrishnan


HBXIP, Accelerys Discovery Studio, Epicatechin.

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version