alexa Abstract | Molecular docking studies between two palladium complexes cis-[(1S, 2S)-(-)-N1, N2-bis(1-phenylethyl)-1,2-propanodiimine]PdCl2and cis-{(1S, 2S)-(-)-N1, N2-bis[1-(4-metilphenyl)ethyl]-1,2-propanodiimine}PdCl2) and DNA for elucidated its possible action mechanism

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access


Cis-diaminedichloroplatinum (II), [cis-(NH 3 ) 2 PtCl 2 ], is one of the most successful anticancer compoun ds. In recent years the search for new drugs with antineoplastic activity has led to synthesis of palladium complexe s, because of its analogy with Platinum (II). The aim in this stu dy was to show the interaction between DNA and pall adium complexes using docking studies, to elucidate the p ossible action mechanism of cis-[(1S, 2S)-(-)-N 1 , N 2 -bis(1- phenylethyl)-1,2-propanodiimine]PdCl 2 and cis-{(1S, 2S)-(-)-N1, N 2 -bis[1-(4-metilphenyl)ethyl]-1,2- propano - diimine}PdCl 2 ). Our results suggest a possible interaction of pa lladium complex and the DNA, forming a covalent bond manner similar to cisplatin.

To read the full article Peer-reviewed Article PDF image

Author(s): Oscar ZuigaLemus Jos Antonio SalgadoZamora Jos Jaime VzquezBravo Veronica CastroBear Francisco L BalderasGmez Rogelio A DelgadoAlfaro Juan Saulo GonzlezGonzlez Jos Alfredo SnchezMera


Cancer, Chemotherapy Drugs, Palladium complex, Molecular Docking, DNA, docking, palladium complexes, DNA

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version