alexa Abstract | Molecular Docking Studies of Isorhamnetin from Corchorus olitorius with Target Alpha-amylase Related to Type 2 Diabetes

Journal of Chemical and Pharmaceutical Research
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Abstract

Type II diabetes (T2DM) is a metabolic disorder arising from impaired insulin action and insulin secretion, which leads to hyperglycemia and also the decimation of the body system. Acarbose, an anti-diabetic drug decreases the postprandial hyperglycemia, by slowing down the absorption of glucose through the inhibition of the carbohydratehydrolyzing enzyme (α–amylase), howbeit with serious side effects. In the present study, with the aid of in silico experiment we have identified isorhamnetin from Corchorus olitorius plant to have a higher inhibitory potential on alpha-amylase (-8.5Kcal/mol) as compared with acarbose (-7.1Kcal/mol) and other compounds (caffeic acid, -6.5 Kcal/mol and chlorogenic acid, -7.3 Kcal/mol) characterized from the same plant (Corchorus olitorius). This study however corroborates the earlier wet experiment on the inhibitory properties of isorhamnetin.

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Author(s): DS Metibemu JA Saliu AO Metibemu OJ Oluwadahunsi G Oboh IO Omotuyi and OA Akinloye

Keywords

Type II diabetes, Acarbose, Isorhamnetin, Chlorogenic acid, caffeic acid and in silico, Molecular Docking

 
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