alexa Abstract | Molecular dynamics study of neurotransmitter reuptake mechanism on modeled transporter proteins

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access

Abstract

The dopamine transporter (DAT), serotonin transporter (SERT) and norepinephrine transporter (NET) proteins are modelled based on homology modelling using Swiss model server. The modelled DAT, SERT and NET were docked with neurotransmitters dopamine, serotonin and norepinephrine respectively using Glide module of Schrodinger suite. At physiological pH, ionic interactions like hydrogen bonding interactions, cation-π interactions and π-π interactions becomes predominate between the neurotransmitter ligands and transporter proteins. It is inferred that from the docking results, phenethylamine appears to be the most important structural element accommodated by the transporter proteins. The perturbation of electronic structure at the residues by the influence of hydrogen bonding interactions, cation-π interactions and π-π interactions is noted as the significant factor in the physiological process.

To read the full article Peer-reviewed Article PDF image

Author(s): Nichodemus M Stephen J Anita Kumari and Sankaran K R

Keywords

Molecular dynamics

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords