alexa Abstract | Monoclonal Antibody Technology : Trends And Prospectus

Indian Journal of Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Review Article Open Access


A fantastic technological breakthrough was achieved by Milstein and Kohler who devised a technique for the production of immortal hybridoma cell lines making monoclonal antibody specific for a single epitope on a complex antigen.The availability of monoclonal antibodies has revived interest in immunotherapy.The ability to influence on individual's immune state by administering immunoglobulin of the appropriate specificity may provide a powerful approach to disease control and prevention. Monoclonal antibodies have tremendous applications In the field of diagnostics, therapeutics, targeted drug delivery systems, not only for infectious disease caused by bacteria, viruses and protozoa but also for cancer, metabolic and hormonal disorders. Looking at the pros and cons of traditional hybridoma technology for the production of monoclonal antibody, recombinant DNA technology has been used to engineer the chimeric monoclonal antibody, complementarity determining regions (CDR) grafted monoclonal antibodies, heteroconjugate antibodies and total recombinant monoclonal antibodies. Genetically engineered human antibody fragments can be derived by expanding the variable heavy (VH) and variable light (VL) chain genes from non-immunized, or preferably immunized donors and expressing them as completely randomised combinatorial libraries on the surface of bacteriophage. Recombinant antibodies can be expressed on a large scale in plants also.

To read the full article Peer-reviewed Article PDF image

Author(s): Smita S Singhania A K Deo P P Bafana

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version