alexa Abstract | Morphological examination of possible pancreotoxic and immunomodulatory action of Co-trimoxazole and corrective action on these effects of extracts of Bupleurumaureum and Hill-growing Saltwort Herb in comparison with Siliborum and Quercetin

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access

Abstract

In the work are presented the results of the morphological examination of possible pancreotoxic and immunomodulatory actions of Bi-tol (co-trimoxazole) and corrective influence of alcohol extracts of Hill-growing Saltwort Herb and Bupleurumaureum at doses of 5 mg / kg and 10 mg / kg. Microscopic examination of the background to the introduction of Bi-tol in some acini of infant rats in some acinus among acini cells and in the lumen of some ducts were observed the appearance of cells that are similar to apoptotic, and in isolated pancreatic islets were observed small cell "loss" of beta-cell nucleus and pycnosis of nucleus and strong cytoplasmic eosinophilia. After intake of extract of Hill-growing Saltwort Herb at a dose of 5 mg / kg on a background of Bi-tol in infant rats condition of acinus and pancreatic islets did not change compared with intact control of the majority of infant rats, as in some animals from the group were found isolated pancreatic islets and a few internal-part ducts containing some similar to apoptotic cells. When using extract of Hill-growing Saltwort Herb at a dose of 10 mg / kg and Bupleurumaureum at doses of 5 mg / kg and 10 mg / kg of changes in the condition of exo- and endocrine part of the pancreas were observed. Thus, the examined extracts helped to reduce the presence of apoptotic cells in modified pancreatic islets and acynosis parenchyma of pancrea of infant rats and dominated by a similar effect of Quercetin were almost equal (especially extract of Bu- pleurumaureum), Siliborum. In immune organs (thymus and spleen ) after intake of Bi-tol (antigenic stimulation) arose standard features of immune response of a definite degree of expressiveness. Examined extracts Hill-growing Saltwort Herb and Bupleurumaureum "soften" the severity of the standard features of the immune response to antigenic stimulation of Bi-tol and such "immunemodulating effect" was at the level of the comparative drugs Quercetin and Sili- borum.

To read the full article Peer-reviewed Article PDF image

Author(s): KhouariSamer Gluschenko A V Georgiyants V A ValyhuraIu G andNaboka O I

Keywords

drug-induced liver injury, sulfanilamide drugs, pancreotoxicity, immune- modulating effect, hepatoprotectors, extract of Bupleurumaureum, extract of Hill-growing Saltwort Herb, histology, immunomodulatory, Plant extract

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

agrifoodaquavet@omicsonline.com

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

clinical_biochem@omicsonline.com

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

business@omicsonline.com

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

chemicaleng_chemistry@omicsonline.com

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

environmentalsci@omicsonline.com

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

engineering@omicsonline.com

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

generalsci_healthcare@omicsonline.com

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

genetics_molbio@omicsonline.com

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

immuno_microbio@omicsonline.com

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

omics@omicsonline.com

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

materialsci@omicsonline.com

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

mathematics_physics@omicsonline.com

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

medical@omicsonline.com

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

neuro_psychology@omicsonline.com

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

pharma@omicsonline.com

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

social_politicalsci@omicsonline.com

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords