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Purpose: The Purpose of the present study was to investigate the possibility of improving the dissolution rate of water insoluble antiemetic drug Domperidone maleate with two different polymers viz. PEG 6000, PVP K25 at different ratios by using various solid dispersion methods. Methods: Solid dispersions of Domperidone maleate were prepared using different ratios of PEG 6000, PVP K25 as carrier by using solvent evaporation method, fusion method and solvent melt method. Results: The prepared solid dispersions were characterized for their drug content, in-vitro solubility, in-vitro dissolution studies, FTIR spectroscopy and DSC were performed to identify physiochemical interaction between the drug and carrier and its effect on dissolution behavior. The prepared formulations showed marked improvement in the solubility and dissolution rate of drug which may be due to decrease in crystallinity of drug and additives. Formulation A4 with 1:4:1 of DOM: PEG6000: PVP K25 gave fast dissolution rate 92.56% of drug when compared to other formulations prepared by different methods at different ratios of pure drug and carriers. Conclusion: The prepared solid dispersion of the Domperidone maleate with PEG and PVP can improve the dissolution rate of the drug (formulation A4 containing 1:4:1). And it can be concluded the solvent evaporation method shows better results compared to fusion method and Solvent Melt method. The solubility and dissolution improvement order is found to be solid evaporation method>Solvent Melt method> fusion method.
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Author(s): UDAY BHASKER GOUD G PRANAV KUMAR AVR JAKKAMPUDI SRI VENUPRAKASH SREENIVAS REDDY G R SAI KRISHNA D M PANGAJANAKI RAMULU
Domperidone maleate, Solubility, Solid dispersion, evaporation method, fusion method, Solvent Melt method, PEG 6000, PVP K25.