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Research Paper Open Access
Pharmacokinetic, parameters were evaluated using multi-fraction absorption model of diltiazem in mongrel dogs. A comparison was made between the conventional one compartment model (model A) and one compartment two-fraction absorption model (model B). It was found from this study that model 1 B could explain the concentration-time profile of diltiazem better compared to model 1A.
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Author(s): Dushyant Shah Chandan Bhave C J Shishoo