alexa Abstract | Nanosuspension versus cyclodextrin inclusion of ciprofloxacin for solubility and dissolution enhancement

Journal of Chemical and Pharmaceutical Research
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Abstract

Objective of this research is to evaluate solubilit y and dissolution of ciprofloxacin using current na notechnology and classical cyclodextrin inclusion complex approa ch. Ciprofloxacin nanosuspension was prepared by an ti solvent precipitation method using pluronic F68 as stabiliz er. Phase solubility study of ciprofloxacin was car ried out alone and with addition of different amount of beta-cyclo dextrin. Solubility studies showed linear increase in aqueous solubility of ciprofloxacin with increase in concen tration of beta cyclodextrin. Inclusion complex of ciprofloxacin was prepared by kneading method. Both nanosuspensio n and inclusion complexes were compared with ciprofloxacin for physicochemical characteristics u sing FT-IR spectroscopy, solubility and dissolution profiles. In vitro dissolution studies revealed there is no sign ificant difference between dissolution profiles of inclusion complexes and nanosuspension however; both showed m ore than two fold higher dissolution as compared to that of pure ciprofloxacin. The finding revealed no signifi cant difference between these two techniques for en hancing solubility and dissolution of ciprofloxacin

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Author(s): M J Ansari M K Anwer M M Ahmed S Jamil and M Althubaiti

Keywords

Ciprofloxacin, nano-suspension, cyclodextrin, solubility, dissolution., Nanosuspension, cyclodextrin, ciprofloxacin

 
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