alexa Abstract | Neuroprotective effect of ethanolic root extract of Boerhaavia diffusa (Linn.) against Streptozotocin induced Diabetic neuropathy in animal model

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access


The present study was designed to screen the neuroprotective effect of Boerhaavia diffusa (Linn.) on Streptozotocine induced diabetic neuropathy in rats. Diabetes was induced in rats with a single intraperitoneal injection of streptozotocin (55 mg/kg b.w). The ethanol extract of B. diffusa at a dose of 100, 200 and 400 mg/kg of body weight were administered at single dose per day to diabetes induced rats for a period of 12 weeks. Neuropathic pain was assessed in diabetic rats with various painful procedures viz., hot and cold water tail immersion test, pinprick test, cold allodynia, hot plate test, photoactometer and rota-rod tests were performed to assess the degree of thermal, mechanical, cold hyperalgesia and locomotor activity as well as motor co-ordination. At the end of the study period experimental animals were scarified and biochemical parameters such as lipid peroxidation, superoxide dismutase, total protein, total calcium levels were evaluated in sciatic nerve tissue. Animals treated with Boerhaavia diffusa (100, 200, and 400 mg/kg p.o.) significantly alleviates hyperglycaemia induced mechanical, thermal hyperalgesia and cold allodynia and restored the reduced body weight and improved the biochemical parameters such as blood sugar levels, superoxide dismutase, and total protein and attenuated the calcium concentration, and lipid peroxidation in a dose dependent manner. Thus, from this study we conclude that Boerhaavia diffusa exhibits significant antidiabetic, antioxidant and neuroprotective activities against streptozotocin-induced diabetic neuropathy in rats.

To read the full article Peer-reviewed Article PDF image

Author(s): Sandeeep Kumar K Jameela Tahashildar and Karunakar Kota


Diabetic, hyperglycemic, Boerhaavia diffusa, streptozotocin, ethanolic

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version