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Original Articles Open Access
Present research is focused on preparation of 2-bromo-4,5-difluoroacetanilide, compound 4, one of the key intermediate mostly used in the preparation of Nadifloxacin, by the bromination of 3,4-difluoroacetanilide compound 3 using novel brominating agent. Current research also identifies specific impurities of Nadifloxacin and origin of its responsible precursors. The present research further provides a new approach to control the amount of these specific impurities in Nadifloxacin by controlling the amount of formation of compounds2b and 2c during the manufacturing process. All prepared compounds are characterized by FT-IR, 1HNMR and LC-MS.
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Author(s): Anil Kumar Bhuwan Bhashkar and Jigar Bhavsar
Preparation of Nadifloxacin, Bromination, Intermediate, Impurities, Precursors, nadifloxacin