alexa Abstract | New approach in treatment of brain injury: Neurotrophic effects of Apigenin

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access


Brain injury initiates a neuroinflammatory cascade that contributes to substantial neuronal damage. Administration of lipopolysaccharide (LPS) impaired antioxidant mechanisms, increased peroxidation and impaired mitochondrial redox activity causing brain inflammation as well as neuronal damage and impairment of brain monoamines. Apigenin gathered extensive attention in recent years because of its chemopreventive, antioxidant and antiinflammatory effects. This study aimed to evaluate the impact of apigenin in LPS induced brain injury in experimental rats and to evaluate its role in monoamines regulation as well as DNA damage reduction. Forty male albino rats were used in this study, divided into four groups (control, apigenin, LPS and treated groups). Brain malondialdehyde (MDA), brain nitric oxide (NO) and serum paraoxnase activity (PON-1) were estimated colorimeterically. DNA damage was evaluated by comet assay method, in addition to brain monoamines assessment by HPLC. Histopathological and Immunohistochemistry of cyclooxygenases (COX-1, COX-2) were also performed. The data showed that lipopolysaccharide significantly increased brain MDA, NO and monoamines concomitant with a reduction in PON-1. Contrarily, apigenin supplementation improved these values in treated group. The present study provides insights into the design of flavonoid with optimal neuroprotective activities.

To read the full article Peer-reviewed Article PDF image

Author(s): J S Hussein Y Abdel Latif M A ElBana D Medhat S Morsy S E ElToukhy A H Farrag L T Abou ElKassem and U H Hawas


Brain injury, apigenin, neurotransmitters, HPLC, DNA damage, cyclooxygenases, brain injury

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version