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Research Article Open Access
A new, simple and sensitive adsorptive stripping voltammetric procedure for determination of paracetamol at a lead film glassy carbon electrode modified with Nafion film (Nafion/PbF/GCE) in pharmaceutical formulations was described. Deposition of lead film on a glassy carbon electrode from 0.1 mol L-1 HNO3 at the potential of -1.4 V was performed. The Nafion film coating was carried out by applying a 0.5 µL drop of 1% (w/v) Nafion solution onto the lead film electrode surface. At the potential of -1.45 V for 60 s paracetamol was accumulated by adsorption on the electrode from 0.1 mol L-1 H2SO4. Experimental results indicate excellent linear correlation between the paracetamol peak current and its concentration in the range from 5 × 10-7 to 1 × 10-2 mol L-1 with accumulation time equal to 60 s. The detection and quantification limits were 1.72 × 10-7 mol L-1 and 5.97 × 10-7 mol L-1, respectively. The elaborated procedure was successfully applied for determination of paracetamol in commercially available pharmaceutical formulations.
Nafion Covered Lead Film Glassy Carbon Electrode, Adsorptive Stripping Determination, Paracetamol Determination, Pharmaceutical Analysis, Voltammetry, Coulometry, Biosensors, Medicine, Pharmacy, Environmental Monitoring