alexa Abstract | New spectrophotometric methods applied to the simultaneous determination of diclofenac potassium and tizanidine

Indian Journal of Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Paper Open Access

Abstract

Simple, sensitive, and specific spectrophotometric methods were developed and validated for quantitation of diclofenac potassium and tizanidine in tablet dosage form. Three new analytical methods were developed based on the simultaneous estimation of drugs in a binary mixture without previous separation. In multiwavelength technique, the binary mixture was determined by mixed standards and three sampling wavelengths of 277 nm, 295 nm (isobestic point), and 320 nm. In simultaneous equation method, the drugs were determined by using the absorptivity values of diclofenac potassium and tizanidine at selected wavelengths, viz., 277 nm and 320.3 nm. The standard deviation value for the validation parameters was found to be between 0.08 and 0.68 for multiwavelength technique and between 0.069 and 1.23 for simultaneous equation method. The graphical absorbance ratio method was performed by absorbances at 277 nm, 295 nm (isobestic point), and 320.4 nm of their mixture. These three methods are simple, accurate, and rapid, and they require no preliminary separation and can therefore be used for routine analysis of both drugs in quality control laboratories.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): R Sanjay Kumar C Karthikeyan N SHN Moorthy P Trivedi

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords