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Research Paper Open Access
Two simple and sensitive spectrophotometric methods (A and B) in the visible region have been developed for the determination of nimesulide in bulk and in dosage forms. Method A is based on the reaction of reduced nimesulide with nitrous acid followed by its coupling with phloroglucinol to yield an yellow colored azo dye with an absorption maximum of 400 nm and method B is based on the reaction of reduced nimesulide with p-dimethylamino benzaldehyde (PDAB) to form an yellow colored chromogen wiht an absorption maximum of 415 nm. The color obeyed Beer's law in the concentration range of 4-20 mg/ml in method A and 4-24 mg/mI in method B. When pharmaceutical preparations (Tablets and suspension) were analysed, the results obtained by the proposed methods are in good agreement with the labelled amounts and are comparable with the results obtained by a reported method. Recovery in both the methods is 98-101%.
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Author(s): K P R Chowdary K Girish Kumar G Devala Rao