alexa Abstract | NGAL as a biomarker to predict and diagnose Acute Kidney Injury (AKI)

Journal of Chemical and Pharmaceutical Research
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Abstract

Neutrophil gelatinase associated lipocalin (NGAL) (also known as Lipocalin 2 or Lcn2) is a small molecule protein (25 Kd) and belongs to the family of the Lipocalins that transport small hydrophobic materials. Studies have shown the benefit of NGAL in predict and diagnose the acute renal injury after 2-3 hours of its occurrence compared with creatinine who needs 2-3 days to rise. Serum levels of NGAL, creatinine and urea were measured in 44 patients divided into patients group with acute renal injury and patients group whose samples were collected after two hours and 3 days from the occurrence of the acute injury. We find high levels of NGAL in patient groups compared with the control group. We also find high levels of NGAL in patients whose sample was collected after two hours of the acute injury while the values of creatinine and urea is within the normal range. However, the three parameters increased in samples taken after three days. The study found that levels of serum NGAL rise in acute renal injury and thus NGAL level can be used as an early biomarker to predict acute renal injury and diagnose it before the elevation of creatinine and urea levels.

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Author(s): Lama Al khouja and Almoutassem Billah Zetoune

Keywords

acute kidney injury, acute renal failure, biomarkers, lipocalin, neutrophil gelatinase associated lipocalin, creatinine, urea.

 
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