alexa Abstract | Nimesulide Incorporated Liquid Micropheres : An Approach To Targeting And Controlled Release

Indian Journal of Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Paper Open Access


Nimesulide, a non-steroidal antiinflammatory drug with very short biological half-life was encapsulated within lipid microspheres by a modified solvent evaporation method with an aim of targeting the drug to the site of inflammation and for controlled release. Physiological lipids such as glyceryl tristearate, cholesterol were used instead of synthetic polymer matrix materials. The prepared lipid microspheres were evaluated with respect to particle size distribution, encapsulation efficiency, in vitro release behaviour and in vivo antiinflammatory activity in rats. Lipid microspheres with a suitable average particle size of 6-7μm could be prepared with this method. The drug was released continuously over 12 days with no burst effect with a maximum release of 74%. The in vivo drug release was investigated in rats, by measuring antiinflammatory activity using cotton pellet granuloma method. A single administration of lipid microspheres showed a better antiinflammatory activity when compared to equivalent multiple administrations of the standard nimesulide solution. The drug concentration was higher in the tissues at the site of inflammation of lipid microspheres treated rats. These results indicated the possibility of drug being released at a controlled rate from lipid microspheres and targeted at the inflamed cells.

To read the full article Peer-reviewed Article PDF image

Author(s): C G Geetha Rao K Vijayanarayana M G Manoj Kumar S Rashmi Radigues D Stayanarayana E V S Subrahmanyam

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version