alexa Abstract | Novel application and spectrophotometric estimation of Melitracen HCl tablet dosage form using Niacinamide as hydrotropic solubilizing agent

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access

Abstract

Various organic solvents like methanol, chloroform, alcohol, dimethyl formamide; acetonitrile, hexane, acetone and carbon tetrachloride have been employed for solubilization of poorly watersoluble drugs for spectrophotometric estimations. Drawbacks of organic solvents include higher cost, toxicity and error in analysis due to volatility. Attempting to minimize these drawbacks, three new, simple, accurate, environmental friendly, cost effective, safe, sensitive spectrophotometric methods have been developed. The primary objective of the present investigation was to employ these hydrotropic solutions to extract the drugs from their dosage forms, precluding the use of costlier organic solvents. Ultraviolet absorption spectrophotometric method for the estimation of poorly water soluble drugs like Melitracen HCl in pharmaceutical formulations has been developed. Aqueous solubilities of this selected model drugs was to a great extent (28 to 35 fold) in 5.0 M niacinamide solutions. The selected λmax for Melitracen HCl were 286.5 nm respectively. The hydrotropic solutions used did not show any absorbance above 306 nm, and therefore, no interference in the estimation was seen. The results of analysis have been validated statistically, and by recovery studies.

To read the full article Peer-reviewed Article PDF image

Author(s): M C Sharma Smita Sharma and A D Sharma

Keywords

Hydrotropic Solubilization, Melitracen HCl, niacinamide., spectrophotometric

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us