alexa Abstract | Novel approach to the synthesis of 3-substituted (1,2,4)triazolo(3,4-b)1,2- benzisoxazole and their antimicrobial activity

Journal of Chemical and Pharmaceutical Research
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Hydroxy benzisoxazole 1 was converted into chlorobenzisoxazole 2 and then to hydrazinobenzisoxazole 3. New tricyclic compounds, triazolobenzisoxazole 4 was obtained from hydrazinobenzisoxazole when treated with formic acid. Similarly 3-hydroxytriazolo benzisoxazole 5 and 3-mercaptotriazolobenzisoxazole were prepared by the action of urea and CS2 in alkali respectively. The compounds have been characterized by elemental analysis and spectral data. Newly synthesized compounds have been screened for their antimicrobial activities against several microbes.

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Author(s): D K Swamy and M V Deshmukh


Triazolobenzisoxazole, 3-hydroxytriazolobenzisoxazole, 3-mercapto triazolobenz - isoxazole, antimicrobial activity.

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