alexa Abstract | Novel Approaches For Drug Delivery To The Brain

Indian Journal of Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Review Article Open Access


The major obstacle in the development of centrally active therapeutics is the lipoidal blood-brain barrier. While a variety of systems to transport compounds into the central nervous system have been designed. The current challenge is to develop drug delivery strategies that will allow the passage of drug molecules through the blood-brain barrier in a safe and effective manner. The invasive approach involves the blood-brain barrier disruption either by osmotically or by using biologically active agents. The above strategies are primarily aimed at short-term application in the treatment regimens of malignant brain tumours while chronic degenerative disorders will require long term application of the therapeutic agent. Owing to this fact non-invasive approach for drug delivery to brain via the systemic route have been developed. Physiological strategy has been to conjugate the therapeutic drug with a protein or a vector or a monoclonal antibody that gains access to the brain by receptor mediated transcytosis. The uses of the drug delivery devices such as liposomes and nanoparticles enhance the penetration of several drugs across the brain. This review will provide an insight into some of the strategies developed to enhance drug delivery across the blood-brain barrier.

To read the full article Peer-reviewed Article PDF image

Author(s): V Soni M K Chourasia Y Gupta A Jain D V Kohli S K Jain

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us