700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ ReadersThis Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
Short Communication Open Access
A novel method of synthesis of curcumin-I has been successfully developed using Claisen- Dieckmann condensation where dehydrozingerone is condensed with methyl ferulate in presence of sodium ethoxide In dimethyl sulphoxide. Various curcuminoids are prepared by changing the esters and Î±, Î²-unsaturated ketones. This reaction is utilized to prepare dehydrozingerone- ibuprofen condensation product (DZIBU), a potent antiinflammatory agent. The homogenecity of compounds synthesized was established and structures were confirmed by spectral data. DZIBU exhibited powerful antiinflammatory activity on carrageenan-induced paw edema model and formaldehyde-induced arthritis model in rats. Though the analgesic activity was less when compared to that of ibuprofen, the new compound did not induce gastrointestinal side effect In animal studies.
To read the full article Peer-reviewed Article PDF
Author(s): P Jayasekhar S B Rao G Santhakumari